- Southwest Cable Communications Association
- Southwest Community Health Center
- Southwest Florida Regional Medical Center
- Southwest Florida Regional Medical Center Transplant Program
- Southwest Gas
- Southwest Louisiana Primary Health Care Center, Inc.
- Southwest Mississippi Regional Medical Center
- Southwest Transplant Alliance
- Southwest Valley YMCA
- Southwestern District Health Unit
- Southwestern Eye Center
- Southwestern Medical Center
- Southwestern Pennsylvania Human Services Inc.
- Southwesterns Pennsylvania Corp.
- SOVAH Health Danville
- Sovah Health Martinsville
- SP Recycling
- Space Center Houston Rotary
- Space Coast Office of Tourism
- Space Imaging
- Space Tables
- Spalding University
- Spang and Company
- Spanish Community Center
- Sparrow Health System
- Spartanburg County Council
- Spartanburg Medical Center
- Spartanburg Medical Center - Mary Black Campus
- Spartanburg Regional Healthcare System
- Spartanburg Restorative Care
- Speare Memorial Hospital
- Special Event Rentals, Inc.
- Specialized Services
- Specialty Hospital Jacksonville
- Spectra Colors Corporation
- Spectra East, Inc.
- Spectranetics Corporation
- Spectrim
- Spectrum Health Big Rapids Hospital
- Spectrum Health Services
- Spectrum Health System
- Spectrum Paralegal
- Speedway SuperAmerica
- Spencer Hospital
- Spherion - Asheville, NC
- Spherion - Glen Allen
- Spherion Professional Recruiting
- SPI Dynamics
- Spindrift Inn, Monterey, CA
- Spiral Inc.