- Sentara Obici Hospital
- Sentara Princess Anne Hospital
- Sentara Virginia Beach General Hospital
- Sentara Williamsburg Regional Medical Center
- Shenandoah Memorial Hospital
- Shenandoah University
- Shenandoah Valley Westminster - Canterbury
- Sheraton National Hotel, Arlington
- Sheraton Norfolk Waterside
- Sheraton Oceanfront Hotel
- Sheraton Reston Hotel, Reston
- Sheraton Suites, Alexandria
- Sherwin Electric Co. Inc.
- Shields Communications Service, Inc.
- Shiloh Baptist Church
- Sierrabay Technology Group
- Silicones Environmental Health Safety Council
- Silverado, Annadale
- Skyline Exhibits-The Holt Group Inc.
- Smiths
- Smyth County Community Hospital
- Snechma USA
- Snerma USA Inc.
- Society of Consumer Affair Professionals in Business
- Society of Government Meeting Professionals
- Society of Independent Gasoline Marketers of America SIGMA)
- Socius Corporation
- SoftEdge Inc.
- Software Solutions
- SourceAmerica
- Southampton Memorial Hospital
- Southeastern Institute of Research, Inc.
- Southern Financial Bank - Horsepen Branch
- Southern Virginia Regional Med Center
- Southern Virginia Regional Medical Center
- Southside Community Hospital - Centra
- Southside Regional Medical Center
- SOVAH Health Danville
- Sovah Health Martinsville
- Specialized Services
- Spherion - Glen Allen
- Spherion Professional Recruiting
- Spokes, ETC
- Spotsylvania Regional Medical Center
- Springhill Suites by Marriott, Chesapeake
- Springhill Suites by Marriott, Norfolk
- Springhill Suites by Marriott, Williamsburg
- SRA
- SRC
- St. Elmo's Coffee Pub