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U.S. Department of Health and Human Services
U.S. Department of Health and Human Services
Organ Donor > Learn > How Donation Works > Living Donation

The Living Donation Process

Most organ and tissue donations occur after the donor has died. But some organs and tissues can be donated while the donor is alive. Nearly 6,000 living donations take place each year. That's about 4 out of every 10 donations.

Most living donations happen among family members or between close friends. Some people become altruistic living donors by choosing to donate to someone they don’t know.

Living donors potentially can donate:

  • One of two kidneys. 
    A kidney is the most frequently donated organ from a living donor. The donor's remaining kidney provides the necessary function needed to remove waste from the body.
  • One of two lobes of their liver.
    Cells in the remaining lobe of the liver grow or regenerate until the liver is almost its original size. This re-growth of the liver occurs in a short period of time in both the donor and recipient.
  • A lung or part of a lung, part of the pancreas, or part of the intestines.
    Although these organs do not regenerate, both the donated portion of the organ and the portion remaining with the donor are fully functioning.

Some of the tissues donated by living donors are:

  • Skin, after certain surgeries such as an abdominoplasty
  • Bone after knee and hip replacements
  • Healthy cells from bone marrow and umbilical cord blood
  • Amnion, donated after childbirth
  • Blood, including white and red blood cells, platelets, and the serum that carries blood cells throughout the circulatory system.

A healthy body can easily replace some tissues such as blood or bone marrow. Both blood and bone marrow can even be donated more than once since they are regenerated and replaced by the body after donation.

Potential living donors are evaluated by the transplant center where they intend to make the donation to determine whether they are suitable to be a donor.

The evaluation is performed to make sure that no adverse physical, psychological, or emotional outcome will occur—before, during, or following the donation.

Generally, living donors should be physically fit, in good health, between the ages of 18 and 60, and should not have (or have had) diabetes, cancer, high blood pressure, kidney disease, or heart disease.

The benefit of saving another by becoming a living donor must be weighed carefully against the risks that come with any major surgical procedure, as well as financial considerations. A healthy donor faces the risk of an unnecessary major surgical procedure and recovery.

  • A small percentage of patients have had problems maintaining life, disability, or medical insurance coverage at the same level and rate as previously.
  • There can be financial concerns due to possible delays in returning to work because of unforeseen medical problems.
  • As with any major surgical procedure, there is a small risk of complications and/or death.

You can find out more information about living kidney donation from the National Kidney Foundation HRSA exit disclaimer or from HRSA exit disclaimer a site in both Spanish and English that discusses financial issues and benefits and risks.

The National Institutes of Health (NIH) is conducting a study to collect information on the outcomes of living donors over time. At present, follow-up reviews of living donors by some transplant centers show that living donors, on average, have done very well over the long term.

However, there is some question about the effects of stress on the remaining organ. There could be subtle medical problems that do not develop until decades after the living donation. The effects are not completely known at this time. To better understand the safety of all living donors, it is critical that the long-term effects of living donation are studied further.

The decision to be a living donor is very personal one. The potential donor must consider the possibility of adverse health effects after donation—as well as the potential to save the life of the recipient, who may be a loved one.

Because we don't know what the short-term and long-term effects to the donor will be, the Federal government does not actively encourage anyone to be a living donor.

However, the Federal government does recognize the wonderful benefit that this gift of life provides to the patient awaiting a transplant and has several ongoing programs to study, support, and protect the living donors who do choose to provide this gift.

The decision to say yes both to organ donation after death and/or as a living donor is the focus of several ongoing and completed research projects conducted across the nation, many of which are supported by the Division of Transplantation, Health Resources and Services Administration, U.S. Department of Health and Human Services.

The Regents of the University of Michigan (Michigan), in partnership with the American Society of Transplant Surgeons (ASTS), has been operating this Program under a cooperative agreement with HRSA since 2006. The National Living Donor Assistance Center (NLDAC) was established to increase access to transplantation, particularly for individuals of lesser financial means. The Program does not promote living organ donation and it has no performance goals for increasing the number of living organ donors. The NLDAC HRSA exit disclaimer helps potential donors with travel, lodging, and meal expenses associated with the organ donation process. These expenses may not be supported under any state compensation program, insurance policy, or under any federal or state health benefits program; by an entity that provides health services on a prepaid basis; or by the recipient of the organ.

 HRSA exit disclaimer

You can find more information about living donation at the United Network for Organ Sharing (UNOS) website on their Living Donation page  HRSA exit disclaimer and at the National Kidney Foundation website on their Living Donation page  HRSA exit disclaimer.

UNOS is the Federal contractor that manages the Organ Procurement and Transplantation Network (OPTN). UNOS also has a toll free number for any questions you may have about living donation, transplant centers, or the transplant process. The number is 1.888.TXINFO1 (894.6361).

How Does It Work?

Watch our video to learn about the organ donation and transplantation process.